We link primary sources - including studies, scientific references, and statistics - within each article and also list them in the resources section at the bottom of our articles. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. A person should weigh the possible benefits and downsides of opioid-containing medications with a doctor before taking any. However, more recent research suggests that if a person uses an opioid in combination with acetaminophen, they may not need to use opioids long term to manage pain. This can severely damage the liver.ĭrugs that do not contain acetaminophen, including those that contain oxycodone only, tend to carry a significantly lower risk of liver damage. Percocet’s addictive potential increases the risk of liver injury, as some people may take significantly more than the recommended dosage. They also announced the addition of Boxed Warning labels to the packaging of these drugs to highlight the risk of liver damage. Later, in 2011, the FDA advised drug manufacturers to limit the amount of acetaminophen in prescription drugs to 325 milligrams (mg) per tablet or less. The agency cautioned that these drugs could cause liver damage and liver failure, especially when a person does not use them properly. In 2009, the FDA recommended that healthcare professionals no longer prescribe acetaminophen-containing drugs, such as Percocet. The most notable additional side effects of Percocet are liver-related problems, such as dark urine. Some people experience more serious side effects, such as:Īs Percocet also contains acetaminophen, it carries more risk of side effects than oxycodone alone. brain fog, a term that people use to describe feeling less alert.Some of the most common side effects of oxycodone include: Percocet and oxycodone can cause many of the same side effects, as oxycodone is an ingredient in Percocet. Percocet contains an amount of acetaminophen similar to that available OTC.Īcetaminophen also affects different receptors alongside the same pain pathway as oxycodone, which means that Percocet may offer more pain relief than oxycodone alone.Īs it contains acetaminophen, Percocet may also help with fever-related symptoms, such as chills, muscle aches, and fatigue. It is available OTC under the brand name Tylenol and also comes in several generic store brands. Using opioids for long-term pain significantly increases the risk of addiction.Īcetaminophen, the other ingredient in Percocet, is a non-opioid pain relief medication that can reduce a fever. They may also prescribe opioids for chronic pain, but the Centers for Disease Control and Prevention (CDC) recommend trying other medications first. Due to this, there is a danger of people misusing opioids and developing an addiction or dependence.ĭoctors usually prescribe opioids when a person has moderate to severe pain, which may result from: Opioids can also trigger a sense of euphoria or sleepiness in some people. Opioids bind to opioid receptors in the brain and spinal cord, blocking certain pain signals. Percocet contains oxycodone, which is an opioid medication. īe sure to check with your doctor or pharmacist when in doubt.Share on Pinterest Education Images/Universal Images Group via Getty Images Pill splitting is also not recommended for situations where the patient might not understand the concept or be capable of splitting a pill. Don't split drugs with an enteric coating (designed to protect the stomach), drugs that are time-release or long-acting, drugs taken more often than once a day, drugs in capsules, and prepackaged drugs in specific doses, like birth control pills. Some immediate-release tablets may be split, and tablets that are scored have been evaluated by the FDA for safety. Pill splitters can be bought at most pharmacies for around $5. Some important things to consider before pill splitting: You'll need to ask your doctor if pill splitting is a good idea for your prescription if so, they will need to adjust your prescription accordingly. While it may seem odd, the 40mg version of the same drug typically does not cost twice as much as the 20mg-in fact, it often costs the exact same amount! Here's how it works: Imagine you take the 20mg dosage of a certain drug. You may be able to save up to 50% each month by splitting a higher dosage of this drug.
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